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Until recently, no therapeutic potential was associated with the other incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), as preclinical studies have suggested potential obesogenic effects

11.8% average weight loss as monotherapy in Phase 3 trialsclinically significant and comparable to first-generation GLP-1 medications

BMC Public Health 2012;12:394

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Khatri, M., Naughton, R

The gastric emptying effects of tirzepatide may significantly impact the absorption and effectiveness of oral medications that require specific timing or absorption patterns